Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study. (13th July 2015)

• Record Type: Journal Article
• Authors: Marzouk, Huda; Lotfy, Hala M.; Farag, Yomna; Rashed, L. A.; El-Garf, Kamal
• Other Names: Al-Mayouf Sulaiman M. Academic Editor.
• Is Part Of: International journal of chronic diseases. Volume 2015(2015)
• Publication Date: 2015-07-13
• Subjects: Chronic diseases -- Periodicals; Chronic Disease; Chronic diseases; Periodicals; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 616.044
• DOI: 10.1155/2015/152616
• Languages: English
• ISSNs: 2356-6981

Abstract

Abstract : Objective . To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods . The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results . High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P = 0.045 ). Conclusion . Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.