Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization. (2nd March 2015)

• Record Type: Journal Article
• Authors: Imamura, Marta; Ezquerro, Fernando; Marcon Alfieri, Fábio; Vilas Boas, Lucy; Tozetto-Mendoza, Tania Regina; Chen, Janini; Özçakar, Levent; Arendt-Nielsen, Lars; Rizzo Battistella, Linamara
• Other Names: Hart David A. Academic Editor.
• Is Part Of: International journal of inflammation. Volume 2015(2015)
• Publication Date: 2015-03-02
• Subjects: Inflammation -- Periodicals; Inflammation; Inflammation; Periodicals; 617.22
• DOI: 10.1155/2015/329792
• Languages: English
• ISSNs: 2090-8040

Abstract

Abstract : Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF- α ) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.