Two new antiplasmodial flavonolignans from the leaves of Cecropia obtusifolia. (June 2019)

• Record Type: Journal Article
• Authors: Rivera-Mondragón, Andrés; Tuenter, Emmy; Bijttebier, Sebastiaan; Cos, Paul; Apers, Sandra; Caballero-George, Catherina; Foubert, Kenn; Pieters, Luc
• Is Part Of: Phytochemistry letters. Volume 31(2019)
• Page Start: 118
• Page End: 120
• Publication Date: 2019-06
• Subjects: Cecropia obtusifolia -- Flavonolignans -- Antiplasmodial activity -- Ent-mururin A -- Ent-vaccinin A; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2019.03.019
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new flavonolignans were isolated from Cecropia obtusifolia . Chemical structures were established on the basis of spectroscopic methods. Ent-mururin A and ent-vaccinin A showed moderate in vitro antiplasmodial activity. Scientific support for the use of Cecropia species against malaria is provided. Abstract: Cecropia species are traditionally used in several Latin American countries to treat various diseases including malaria. A phytochemical investigation on the leaves of Cecropia obtusifolia Bertol (Urticaceae) afforded two new flavonolignans, i.e. ent-mururin A (1 ) and ent-vaccinin A (2 ). They were isolated by means of chromatographic techniques and elucidated based on their spectroscopic (NMR, MS and optical rotation) data, and were described as new isomers of mururin A and vaccinin A. Antiplasmodial evaluation revealed that1 and2 were moderately active in vitro against the chloroquine-resistant strain Plasmodium falciparum K1 (IC50 4.68 μM and 7.34 μM, respectively) without cytotoxic effects up to a concentration of 64.0 μM.