Four meroterpenoids from Alternaria alternata isolated from Paeonia lactiflora. (June 2019)

• Record Type: Journal Article
• Authors: Wang, Ju-Tao; Ma, Zong-Hui; Wang, Guo-Kai; Xu, Feng-Qing; Chen, Lin; Yu, Yang; Wang, Gang; Liu, Jin-Song
• Is Part Of: Phytochemistry letters. Volume 31(2019)
• Page Start: 1
• Page End: 4
• Publication Date: 2019-06
• Subjects: Alternaria alternata -- Meroterpenoids -- TCAs -- Cytotoxic activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2019.03.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Four new natural meroterpenoids, tricycloalternarenes (TCAs) compounds were isolated from Alternaria alternate . Four new TCAs were elucidated by in-depth analyses of NMR spectra, HRESIMS and optical rotation experiments. Cytotoxic activities against five selected tested tumor cell lines of four new TCAs were evaluated. Abstract: Four new natural meroterpenoids, tricycloalternarenes (TCAs)15b‒18b (1 ‒4 ) along with four known TCAs (5 ‒8 ) have been isolated from the fermentation broth of Alternaria alternata derived from Paeonia lactiflora . The structures of compounds1 ‒4 were elucidated by in-depth analyses of NMR spectra, HRESIMS and optical rotation experiments. Cytotoxic activities of1 ‒4 against five selected tumor cell lines were evaluated.