Deoxybenzoin and flavan derivatives from the twigs of Artocarpus lakoocha. (June 2019)

• Record Type: Journal Article
• Authors: Boonyaketgoson, Sirada; Rukachaisirikul, Vatcharin; Phongpaichit, Souwalak; Trisuwan, Kongkiat
• Is Part Of: Phytochemistry letters. Volume 31(2019)
• Page Start: 96
• Page End: 100
• Publication Date: 2019-06
• Subjects: Artocarpus lakoocha -- Moraceae -- Antibacterial activity -- Acetylcholinesterase inhibitory activity -- Antimalarial activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2019.03.020
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new and seventeen known compounds were isolated from the twigs of A. lakoocha . Structures were elucidated by 1D and 2D NMR spectrometry. They showed strong antibacterial and antifungal activities. Some compounds exhibited antimalarial and acetylcholinesterase inhibitory activity. This is the first report of the isolated compounds having antimicrobial activities. Abstract: One new deoxybenzoin, named lakoochanoside A (1 ), and one new flavan, named lakoochanoside B (2 ), along with 17 known compounds were isolated and identified from the twigs of Artocarpus lakoocha. The structures of isolated compounds were elucidated by spectroscopic methods, especially 1D and 2D NMR spectroscopy. Cycloartocarpin (14 ) exhibited strong antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus with the same MIC values of 2 μg/mL. It also displayed antimalarial activity against Plasmodium falciparum K1 with an IC50 value of 2.66 μM.