New cassane diterpenoids from the root bark of Erythrophleum suaveolens. (June 2019)

• Record Type: Journal Article
• Authors: Konan, Jacques Dibi; Attioua, Barthélemy Koffi; Kablan, Claude Landry Ahmont; Kabran, Faustin Aka; Koffi, Paul Armand; Any-Grah, Sandrine Aka; Drissa, Sissouma; Seon-Meniel, Blandine; LeBlanc, Karine; Jullian, Jean-Christophe; Beniddir, Mehdi A.
• Is Part Of: Phytochemistry letters. Volume 31(2019)
• Page Start: 166
• Page End: 169
• Publication Date: 2019-06
• Subjects: Erythrophleum suaveolens -- Fabaceae -- cassane diterpenoids -- amine -- amide; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2019.04.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical Abstract: Highlights: The methanol extract from the root barks of Erythrophleum suaveolens was fractionated Nine Cassane diterpenoid amines and amides were isolated from Erythrophleum suaveolens. Two new cassane diterpenoids were identified The structural determinations were made by the mean of spectroscopy analysis. Abstract: Phytochemical investigation of the methanol extract from the root barks of Erythrophleum suaveolens (Guill. et Perr.) Brenan led to the isolation of four cassane diterpenoid amides and five cassane diterpenoid amines. Among these compounds, two were considered as new structures: 3 β -hydroxy-3-methylbutanoyloxy-6 α -hydroxy- nor -cassamine (1 ) and 3 β -hydroxy-3-methylbutanoyloxy-erythrosuamine (2 ). Compounds3 (3 β -acetoxy- nor -erythrosuamine), 4 ( nor -cassamine), 5 (6 α -hydroxy- nor -cassamine), 6 (3 β -hydroxy-erythrosuamide), 7 (6 α -hydroxy- nor -erythrophlamide), 8 ( nor -cassaidide) and9 ( nor -cassamidide) were known. Their structures were established by spectral analysis including MS, IR, 1D and 2D-NMR spectroscopy. The originality of this study lies in the fact that two new natural molecules were identified and all the isolated compounds (1-9 ) were reported for the first time from the root barks of E. suaveolens .