Toonamicronoids A–D, four new B-seco-limonoids from Toona microcarpa. (June 2019)

• Record Type: Journal Article
• Authors: Zhang, Ling; Xia, Jianjun; Yang, Jianyun; Zhu, Long; Tang, Danyu; Ma, Ji; Zhao, Yingliang; Zeng, Xiaoying; Qiu, Minghua
• Is Part Of: Phytochemistry letters. Volume 31(2019)
• Page Start: 225
• Page End: 228
• Publication Date: 2019-06
• Subjects: Toona microcarpa -- Toonamicronoids A–D -- Limonoid -- Identification -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2019.04.010
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Four new B- seco -Limonoids were isolated from T. microcarpa . Their structures were identified on the basis of MS and NMR analysis. Compounds1 and4 showed moderate cytotoxicities against HL-60. Abstract: Four new B- seco -limonoids, toonamicronoids A–D (1 –4 ), together with four known ones, toonaciliatin H–J (5 –7 ), and toonacilianin A (8 ), were isolated from Toona microcarpa . Their structures were identified on the basis of ESIMS, HREIMS and 1D/2D NMR analysis. Compounds1 and4 showed moderate cytotoxicities against HL-60 with the IC50 values of 17.3 ± 1.5 and 22.7 ± 1.9 μM, respectively.