Long-term shedding of Canine alphaherpesvirus 1 in naturally infected newborn pups. (August 2018)

• Record Type: Journal Article
• Authors: Losurdo, Michele; Dowgier, Giulia; Lucente, Maria Stella; Cinone, Mario; Camero, Michele; Colaianni, Maria Loredana; Passantino, Giuseppe; Ventriglia, Gianluca; Buonavoglia, Domenico; Decaro, Nicola
• Is Part Of: Research in veterinary science. Volume 119(2018)
• Page Start: 244
• Page End: 246
• Publication Date: 2018-08
• Subjects: Dog -- Canine alphaherpesvirus -- Viral shedding -- Neonatal infection; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2018.07.001
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: The long-term shedding of Canine alphaherpesvirus 1 (CaHV-1) by neonatal pups with natural infection is reported. The pups belonged to a litter of 11 pointers of a breeding kennel in southern Italy, 9 of which developed a fatal form of systemic infection, as resulted by the detection of CaHV-1 in internal organs (kidney, liver, lung and brain) of one of this dogs and in the vaginal swab of their mother. The two remaining animals displayed a milder form of disease, with one pup showing ocular involvement, and underwent a progressive recovery. These pups were monitored from 11 to 36 days of age, showing a long-term shedding of the virus through the nasal and ocular secretions and the faeces. CaHV-1 shedding, as assessed by means of a specific and sensitive real-time PCR assay, occurred mainly through the nasal secretions, although the pup displaying ocular disease shed the virus at high titres and for a long period even in the ocular secretions. Highlights: Two newborn pups with natural Canine alphaherpesvirus 1 infection were monitored up to 36 days of age. A long-term viral shedding was observed. The highest viral titres were detected in the ocular and nasal secretions. This study contributes to expand the knowledge about Canine alphaherpesvirus 1 biology.