Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD. (22nd November 2016)

• Record Type: Journal Article
• Authors: Nakajima, Takahiro; Nakamura, Hidetoshi; Owen, Caroline A.; Yoshida, Shuichi; Tsuduki, Keishi; Chubachi, Shotaro; Shirahata, Toru; Mashimo, Shuko; Nakamura, Miho; Takahashi, Saeko; Minematsu, Naoto; Tateno, Hiroki; Fujishima, Seitaro; Asano, Koichiro; Celli, Bartolome R.; Betsuyaku, Tomoko
• Other Names: Corsi Romanelli Massimiliano M. Academic Editor.
• Is Part Of: Disease markers. Volume 2016(2016)
• Publication Date: 2016-11-22
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2016/4093870
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Purpose . This study aimed to examine whether plasma levels of cathepsin S or its inhibitor, cystatin C, may serve as biomarkers for COPD. Patients and Methods . We measured anthropometrics and performed pulmonary function tests and chest CT scans on 94 patients with COPD and 31 subjects with productive cough but no airflow obstruction ("at risk"; AR). In these subjects and in 52 healthy nonsmokers (NS) and 66 healthy smokers (HS) we measured plasma concentrations of cathepsin S and cystatin C using an ELISA. Data were analyzed using simple and logistic regression and receiver operating characteristic analyses. Results . Cathepsin S and cystatin C plasma levels were significantly higher in the COPD and AR groups than in the NS and HS groups (p < 0.01 ). Among the COPD patients and AR subjects, plasma cathepsin S levels and cathepsin S/cystatin C ratios, but not cystatin C levels, were negatively related to severe airflow limitation (% FEV1 predicted < 50%;p = 0.005 ) and severe emphysema as assessed by low attenuation area (LAA) score on chest CT scans (LAA≥ 8.0;p = 0.001 ). Conclusion . Plasma cathepsin S and cathepsin S/cystatin C ratios may serve as potential biomarkers for COPD.