Uric Acid as a Marker of Kidney Disease: Review of the Current Literature. (27th May 2015)

• Record Type: Journal Article
• Authors: Giordano, Christin; Karasik, Olga; King-Morris, Kelli; Asmar, Abdo
• Other Names: Murdaca Giuseppe Academic Editor.
• Is Part Of: Disease markers. Volume 2015(2015)
• Publication Date: 2015-05-27
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2015/382918
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.