Prognostic Role of MicroRNA-210 in Various Carcinomas: A Systematic Review and Meta-Analysis. (23rd January 2014)

• Record Type: Journal Article
• Authors: Li, Minmin; Ma, Xuelei; Li, Mei; Zhang, Binglan; Huang, Juan; Liu, Lei; Wei, Yuquan
• Other Names: Block Timothy M. Academic Editor.
• Is Part Of: Disease markers. Volume 2014(2014)
• Publication Date: 2014-01-23
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2014/106197
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Objective . Many studies have shown that microRNAs (miRNAs) could play a potential role as prognostic biomarkers of tumors. The aim of this study is to summarize the global predicting role of microRNA-210 (miR-210) for survival in patients with a variety of carcinomas. Methods . Relevant literature was identified using PubMed and the information in eligible studies has been extracted. Then meta-analysis of hazard ratio (HR) was performed to evaluate the prognostic role of the miR-210 in different tumors. Results . This meta-analysis included 9 published studies dealing with various carcinomas. For recurrence free survival or disease free survival (RFS/DFS), the combined hazard ratio (HR) and 95% confidence interval (95% CI) of higher miR-210 expression were 2.47 [1.36, 4.46], which could significantly predict poor survival in general carcinomas. MicroRNA-210 was also a significant predictor for overall survival (OS), metastasis free survival or distant relapse free survival (MFS/DRFS), and disease specific survival (DSS). Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse RFS/DFS, OS, and MFS/DRFS, especially in breast cancer, which were 3.36 [2.30, 4.93], 3.29 [1.65, 6.58], and 2.85 [1.76, 4.62] separately. Conclusion . Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers.