Biomarkers of Lung Injury in Cardiothoracic Surgery. (17th March 2015)

• Record Type: Journal Article
• Authors: Engels, Gerwin Erik; van Oeveren, Willem
• Other Names: Pich Andreas Academic Editor.
• Is Part Of: Disease markers. Volume 2015(2015)
• Publication Date: 2015-03-17
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2015/472360
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series of physiological changes, but comprehensive research is focused on determining biomarkers for early diagnosis of pulmonary dysfunction. Here we discuss the use of biomarkers of lung injury in cardiothoracic surgery and their ability to detect subtle pulmonary dysfunction in the perioperative period. Degranulation products of neutrophils are often used as biomarker since they have detrimental effects on the pulmonary tissue by themselves. However, these substances are not lung specific. Lung epithelium specific proteins offer more specificity and slowly find their way into clinical studies.