Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma. (30th April 2015)

• Record Type: Journal Article
• Authors: Taioli, Emanuela; Wolf, Andrea S.; Moline, Jacqueline M.; Camacho-Rivera, Marlene; Flores, Raja M.
• Other Names: Bamonti Fabrizia Academic Editor.
• Is Part Of: Disease markers. Volume 2015(2015)
• Publication Date: 2015-04-30
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2015/282145
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Introduction . Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival. Methods . All cases of pathologically proven MPM were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed according to self-reported race (black or white). Results . There were 13, 046 white and 688 black MPM patients (incidence: 1.1 per 100, 000 whites; 0.5 per 100, 000 blacks; age-adjusted, p = 0.01 ). Black patients were more likely to be female, younger, and with advanced stage and less likely to undergo cancer-directed surgery than whites, after adjustment by stage. On multivariable analysis, younger age and having surgery were associated with longer survival for both cohorts; female gender (HR 0.82 (0.77–0.88)) and early stage at diagnosis (HR 0.83 (0.76–0.90)) were predictive of longer survival in white, but not in black, patients. Conclusions . Surgery was associated with improved survival for both black and white MPM patients. However, black patients were less likely to undergo cancer-directed surgery. Increased surgical intervention in MPM black patients with early stage disease may improve their survival.