Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection. (24th February 2015)

• Record Type: Journal Article
• Authors: Bonfim Freitas, Felipe; Souza Lima, Sandra; Feitosa, Rosimar Neris Martins; Azevedo, Vânia Nakauth; Ishak, Marluísa de O. Guimarães; Ishak, Ricardo; Vallinoto, Antonio Carlos R.
• Other Names: Frieling Helge Academic Editor.
• Is Part Of: Disease markers. Volume 2015(2015)
• Publication Date: 2015-02-24
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2015/248571
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Objective. This study investigated possible associations between the TNF α -308G/A, IFN+874A/T, IL-6-174C/G, IL-10-1082A/G, and TGFβ -509C/T polymorphisms with HIV-1 infection, in addition to correlation of the polymorphisms with clinical markers of AIDS progression, such as levels of CD4+/CD8+ T lymphocytes and plasma viral load. Methods. A total of 216 individuals who were infected with HIV-1 and on antiretroviral therapy (ART) and 294 individuals from the uninfected control group were analyzed. Results. All individuals evaluated were negative for total anti-HBc, anti-HCV, anti- T. pallidum, and anti-HTLV-1/2. The polymorphisms were identified by PCR-RFLP. Individuals presenting the IFN+874A allele as well as the AA genotype were more frequent in the HIV-1 infected group compared to the control group (P < 0.05 ), in addition to having lower levels of CD4+ T lymphocytes. The CD8+ T lymphocytes count was significantly lower in individuals with the IL-10-1082 GG genotype. The TGFβ -509TT genotype was associated with higher plasma viral load. Conclusions. The results suggest that the presence of the IFN+874A allele confers susceptibility to HIV-1 infection and a decrease in the number of CD4+ T lymphocytes. In addition, the genotype associated with high serum levels of TGFβ may be associated with an increase in plasma viral load.