Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Issue 7 (July 2016)

• Record Type: Journal Article
• Authors: Kai, FuiBoon; Laklai, Hanane; Weaver, Valerie M.
• Is Part Of: Trends in cell biology. Volume 26:Issue 7(2016)
• Page Start: 486
• Page End: 497
• Publication Date: 2016-07
• Subjects: extracellular matrix stiffness -- migration -- invasion -- cancer -- fibrosis -- cardiovascular disease; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2016.03.007
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression. Trends: Fibrotic diseases frequently coincide with stiffened ECMs, and the elevated migration and invasion of resident and exogenous cells. A stiff matrix fosters the formation of actin-rich invadosomes and lamellae. Invadosomes and lamellae are essential subcellular machineries driving cell invasion and migration. Reducing invadosome and lamella formation (and, thus, cellular invasion) through the therapeutic targeting of tissue tension and mechanosignaling could ameliorate disease pathology.