Regulatory identification of BPA as an endocrine disruptor: Context and methodology. (5th November 2018)

• Record Type: Journal Article
• Authors: Beausoleil, Claire; Emond, Claude; Cravedi, Jean-Pierre; Antignac, Jean-Philippe; Applanat, Martine; Appenzeller, Brice R.; Beaudouin, Remy; Belzunces, Luc P.; Canivenc-Lavier, Marie-Chantal; Chevalier, Nicolas; Chevrier, Cécile; Elefant, Elisabeth; Eustache, Florence; Habert, René; Kolf-Clauw, Martine; Le Magueresse-Battistoni, Brigitte; Mhaouty-Kodja, Sakina; Minier, Christophe; Multigner, Luc; Schroeder, Henri; Thonneau, Patrick; Viguié, Catherine; Pouzaud, François; Ormsby, Jean-Nicolas; Rousselle, Christophe; Verines-Jouin, Lauranne; Pasquier, Elodie; Michel, Cécile
• Is Part Of: Molecular and cellular endocrinology. Volume 475(2018)
• Page Start: 4
• Page End: 9
• Publication Date: 2018-11-05
• Subjects: Bisphenol A -- Endocrine disruption -- ED -- SVHC -- Substance of very high concern -- REACh; ANSES Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'environnement et du travail (French Agency for Food, Environmental and Occupational Health & Safety) -- AOP adverse outcome pathway -- BPA bisphenol A -- CD compact disc -- CLP Classification, Labelling and Packaging -- CMR Carcinogen, Mutagen, Reprotoxic -- DES diethylstilbestrol -- E2 17-β estradiol -- EC European Commission -- ECHA European Chemical Agency -- ED endocrine disruptor -- EDC endocrine disrupting chemical -- EZH2 Enhancer of Zeste Homolog 2 -- HOTAIR HOX transcript antisense RNA -- JRC Joint Research Center, the European Commission's in-house science service -- MoA mode of action -- OECD Organisation for Economic Co-operation and Development -- REACH Registration, Evaluation, Authorisation and Restriction of Chemicals -- SVHC substance of very high concern -- WHO World Health Organization -- WoE weight of evidence; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2018.02.001
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies. The analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA. Highlights: BPA is an ubiquitous substance due to its multiple and large uses. BPA is closely associated with ongoing controversies related to ED. Regulation of ED is in its early stages and requires a high level of evidence. Several ED-mediated effects of BPA achieve these requirements.