Remodeling our concept of chemokine receptor function: From monomers to oligomers. Issue 2 (2nd May 2018)

• Record Type: Journal Article
• Authors: Martínez‐Muñoz, Laura; Villares, Ricardo; Rodríguez‐Fernández, José Luis; Rodríguez‐Frade, José Miguel; Mellado, Mario
• Other Names: Graham Gerard guestEditor.; Moser Bernhard guestEditor.; Thelen Marcus guestEditor.
• Is Part Of: Journal of leukocyte biology. Volume 104:Issue 2(2018)
• Page Start: 323
• Page End: 331
• Publication Date: 2018-05-02
• Subjects: cell signaling -- chemokine receptors -- imaging‐based approaches -- receptor conformations; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.2MR1217-503R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: The chemokines direct leukocyte recruitment in both homeostatic and inflammatory conditions, and are therefore critical for immune reactions. By binding to members of the class A G protein‐coupled receptors, the chemokines play an essential role in numerous physiological and pathological processes. In the last quarter century, the field has accumulated much information regarding the implications of these molecules in different immune processes, as well as mechanistic insight into the signaling events activated through their binding to their receptors. Here, we will focus on chemokine receptors and how new methodological approaches have underscored the role of their conformations in chemokine functions. Advances in biophysical‐based techniques show that chemokines and their receptors act in very complex networks and therefore should not be considered isolated entities. In this regard, the chemokine receptors can form homo‐ and heterodimers as well as oligomers at the cell surface. These findings are changing our view as to how chemokines influence cell biology, identify partners that regulate chemokine function, and open new avenues for therapeutic intervention. Abstract : New imaging‐based approaches reveal a complex, dynamic picture of cell membrane chemokine receptors that define ligand‐mediated functions.