Metabolic regulation of leukocyte motility and migration. Issue 2 (16th February 2018)

• Record Type: Journal Article
• Authors: Marelli‐Berg, Federica M.; Jangani, Maryam
• Other Names: Graham Gerard guestEditor.; Moser Bernhard guestEditor.; Thelen Marcus guestEditor.
• Is Part Of: Journal of leukocyte biology. Volume 104:Issue 2(2018)
• Page Start: 285
• Page End: 293
• Publication Date: 2018-02-16
• Subjects: Cells: Dendritic -- Cells: Monocytes/Macrophages -- Cells: Neutrophils -- Cells: T Lymphocytes -- Molecules: Adhesion Molecules -- Molecules: Chemokines -- Molecules: Integrins -- Molecules: Signaling Cascade -- Process: Cell Trafficking/Adhesion; Leucocytes -- Periodicals; Reticulo-endothelial system -- Periodicals; 571.96
• DOI: 10.1002/JLB.1MR1117-472R
• Languages: English
• ISSNs: 0741-5400

Abstract

Abstract: Dynamic reorganization of the cytoskeleton is essential for numerous cellular processes including leukocyte migration. This process presents a substantial bioenergetic challenge to migrating cells as actin polymerization is dependent on ATP hydrolysis. Hence, migrating cells must increase ATP production to meet the increased metabolic demands of cytoskeletal reorganization. Despite this long‐standing evidence, the metabolic regulation of leukocyte motility and trafficking has only recently begun to be investigated. In this review, we will summarize current knowledge of the crosstalk between cell metabolism and the cytoskeleton in leukocytes, and discuss the concept that leukocyte metabolism may reprogram in response to migratory stimuli and the different environmental cues received during recirculation ultimately regulating leukocyte motility and migration. Abstract : Review on regulation of leukocyte migration by metabolic pathways induced by adhesion and chemokine receptors.