Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp3)−H Bond Activation. Issue 4 (19th December 2016)

• Record Type: Journal Article
• Authors: Yada, Akira; Liao, Wenqing; Sato, Yuta; Murakami, Masahiro
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 4(2017)
• Page Start: 1073
• Page End: 1076
• Publication Date: 2016-12-19
• Subjects: amines -- arylation -- C−H activation -- palladium -- reaction mechanisms; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201610666
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A palladium‐catalyzed reaction of primary amines with iodoarenes produces γ‐arylated primary amines. A bulky salicylaldehyde, which is marked as easily available, installable, removable, and recoverable, plays a key role in directing palladium to site‐selectively activate the C−H bond located γ to the amino group. Abstract : Added bulk : A palladium‐catalyzed reaction of primary amines with iodoarenes produces γ‐arylated primary amines. A buttressing salicylaldehyde, which is easily available, installable, removable, and recoverable, plays a key role in directing palladium to site‐selectively activate the C−H bond located γ to the amino group.