Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation. (19th December 2016)

• Record Type: Journal Article
• Authors: Zhang, Qing‐Wei; An, Kun; Liu, Li‐Chuan; Zhang, Qi; Guo, Huifang; He, Wei
• Is Part Of: Angewandte Chemie. Volume 129:Number 4(2017)
• Page Start: 1145
• Page End: 1149
• Publication Date: 2016-12-19
• Subjects: Dibenzosilole -- Enantioselektivität -- Silacyclobutane -- Tetraorganosiliciumverbindungen; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201609022
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization–dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee . Chiral TMS‐segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.