The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis. (2nd January 2016)

• Record Type: Journal Article
• Authors: Shen, Jia; Sheng, Xiangpeng; Chang, ZeNan; Wu, Qian; Xie, Dong; Wang, Fudi; Hu, Ronggui
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 1(2016)
• Publication Date: 2016-01-02
• Subjects: heme -- p53 -- iron deprivation -- nuclear export -- hemochromatosis -- tumorigenesis; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.4161/23723548.2014.965642
• Languages: English
• ISSNs: 2372-3556

Abstract

Abstract : Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.