TRAMM, a new player in CENP-E biology. (2nd January 2016)

• Record Type: Journal Article
• Authors: Milev, Miroslav P.; Sacher, Michael
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 1(2016)
• Publication Date: 2016-01-02
• Subjects: CENP-E -- chromosome congression -- mitosis -- TRAPP -- TRAMM; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1057314
• Languages: English
• ISSNs: 2372-3556

Abstract

Abstract: Mitosis is a highly orchestrated process with morphologically defined stages and is subject to checkpoints that ensure the proper distribution of chromosomes. Centromere-associated protein E (CENP-E), a protein expressed during mitosis, is a potential target of cancer therapeutics. Our laboratory has recently implicated a protein called TRAMM (trafficking of membranes and mitosis) in the recruitment of CENP-E to kinetochores.