Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer. (2nd January 2016)

• Record Type: Journal Article
• Authors: Cook, Katherine L; Schwartz-Roberts, Jessica L; Baumann, William T; Clarke, Robert
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 1(2016)
• Publication Date: 2016-01-02
• Subjects: ATG7 -- autophagy -- breast cancer -- estrogen receptor -- IRF1 tumor suppressor -- unfolded protein response; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1023928
• Languages: English
• ISSNs: 2372-3556

Abstract

Abstract : Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.