When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers. (2nd January 2016)

• Record Type: Journal Article
• Authors: McCabe, Nuala; Walker, Steven M; Kennedy, Richard D
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 1(2016)
• Publication Date: 2016-01-02
• Subjects: ATM -- DNA damage -- DSB -- PTEN -- ROS; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1053595
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and phosphatase and tensin homolog (PTEN) loss that was the result of increased oxidative stress. Inhibition of ATM therefore represents a novel strategy to target PTEN-associated cancers.