C-reactive protein-albumin ratio is an independent prognostic predictor of tumor recurrence in stage IIIA-N2 lung adenocarcinoma patients. (December 2017)

• Record Type: Journal Article
• Authors: Yamauchi, Yoshikane; Safi, Seyer; Muley, Thomas; Warth, Arne; Herth, Felix J.F.; Dienemann, Hendrik; Hoffmann, Hans; Eichhorn, Martin E.
• Is Part Of: Lung cancer. Volume 114(2017)
• Page Start: 62
• Page End: 67
• Publication Date: 2017-12
• Subjects: Lung adenocarcinoma -- NSCLC stage IIIA -- C-reactive protein-albumin ratio -- Inflammation -- Nutrition -- Prognostic marker; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2017.11.002
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: The prognostic value of nutrition/inflammation-based markers were evaluated. The optimal cutoff value for C-reactive protein/albumin ratio (CAR) was defined. CAR is an independent predictor in stage IIIA lung adenocarcinoma patients. Abstract: Objective: To systematically evaluate the prognostic value of nutrition/inflammation-based markers for recurrence-free survival (RFS) in pN2-stage IIIA lung adenocarcinoma patients. Materials and methods: Data from 156 patients who had pathologically confirmed pN2-stage IIIA primary lung adenocarcinoma and received complete surgical resection from 2010 to 2014 were retrospectively analyzed. The data for Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS, C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and prognostic nutritional index were analyzed. Univariate and multivariate Cox proportional-hazards regression analyses were used to identify the prognostic factors associated with RFS. Results: The optimal cutoff value for the CAR was set at 0.6. A significant correlation was found between the CAR and RFS (P = 0.001) by univariate analysis. Multivariate analysis between RFS and the factors selected from univariate analysis showed that ECOG performance status, pneumonectomy, multi-level N2, and high CAR were independent predictors of RFS. Conclusion: The CAR was the best prognostic marker to predict tumor recurrence in pN2-stage IIIA lung adenocarcinoma patients among the 7 nutrition/inflammation-based markers. The preoperative CAR may identify patients with a high risk of postoperative tumor recurrence.