Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels. (February 2018)

• Record Type: Journal Article
• Authors: Mora, Ana M.; Fleisch, Abby F.; Rifas-Shiman, Sheryl L.; Woo Baidal, Jennifer A.; Pardo, Larissa; Webster, Thomas F.; Calafat, Antonia M.; Ye, Xiaoyun; Oken, Emily; Sagiv, Sharon K.
• Is Part Of: Environment international. Volume 111(2018)
• Page Start: 1
• Page End: 13
• Publication Date: 2018-02
• Subjects: ALT alanine aminotransferase -- BMI body mass index -- CDC Centers for Disease Control and Prevention -- CI confidence interval -- EtFOSAA 2-(N-ethyl-perfluorooctane sulfonamido) acetate -- GAM generalized additive models -- GFR glomerular filtration rate -- HDL-C high-density lipoprotein cholesterol -- IQR interquartile range -- LDL-C low-density lipoprotein cholesterol -- LOD limit of detection -- MeFOSAA 2-(N-methyl-perfluorooctane sulfonamido) acetate -- n-PFOA n-perfluorooctanoate -- n-PFOS n-perfluorooctane sulfonate -- NAFLD nonalcoholic fatty liver disease -- PFAS per- and polyfluoroalkyl substances -- PFDeA perfluorodecanoate -- PFHxS perfluorohexane sulfonate -- PFNA perfluorononanoate -- PFOA perfluorooctanoate -- PFOS perfluorooctane sulfonate -- PFOSA perfluorooctane sulfonamide -- PPAR peroxisome proliferator-activated receptor -- TC total cholesterol -- TG triglycerides -- Sb-PFOA branched perfluorooctanoates -- Sm-PFOS perfluoromethylheptane sulfonates -- Sm2-PFOS perfluorodimethylhexane sulfonates; Per- and polyfluoroalkyl substances -- Lipids -- Liver function -- Pregnancy -- Childhood; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2017.11.008
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Growing evidence suggests that exposure to per- and polyfluoroalkyl substances (PFASs) may disrupt lipid homeostasis and liver function, but data in children are limited. Objective: We examined the association of prenatal and mid-childhood PFAS exposure with lipids and alanine aminotransferase (ALT) levels in children. Methods: We studied 682 mother-child pairs from a Boston-area pre-birth cohort. We quantified PFASs in maternal plasma collected in pregnancy (median 9.7 weeks gestation, 1999–2002) and in child plasma collected in mid-childhood (median age 7.7 years, 2007–2010). In mid-childhood we also measured fasting total (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and ALT. We then derived low-density lipoprotein cholesterol (LDL-C) from TC, HDL-C, and TG using the Friedewald formula. Results: Median (interquartile range, IQR) perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorodecanoate (PFDeA) concentrations in child plasma were 6.2 (5.5), 4.3 (3.0), and 0.3 (0.3) ng/mL, respectively. Among girls, higher child PFOS, PFOA, and PFDeA concentrations were associated with detrimental changes in the lipid profile, including higher TC and/or LDL-C [e.g., β per IQR increment in PFOS = 4.0 mg/dL (95% CI: 0.3, 7.8) for TC and 2.6 mg/dL (−0.5, 5.8) for LDL-C]. However, among both boys and girls, higher plasma concentrations of these child PFASs were also associated with higher HDL-C, which predicts better cardiovascular health, and slightly lower ALT, which may indicate better liver function. Prenatal PFAS concentrations were also modestly associated with improved childhood lipid and ALT levels. Conclusions: Our data suggest that prenatal and mid-childhood PFAS exposure may be associated with modest, but somewhat conflicting changes in the lipid profile and ALT levels in children. Highlights: Measured PFASs in maternal plasma in pregnancy and child plasma in mid-childhood Measured fasting lipids and ALT in mid-childhood Child PFASs associated with higher TC and LDL-C among girls Maternal and child PFASs associated with higher HDL-C and lower TG among girls Maternal and child PFASs associated with decreased ALT levels