Emerging evidence for the essential role of hyaluronan in cutaneous biology. Issue 1 (April 2019)

• Record Type: Journal Article
• Authors: Muto, Jun; Sayama, Koji; Gallo, Richard L.; Kimata, Koji
• Is Part Of: Journal of dermatological science. Volume 94:Issue 1(2019)
• Page Start: 190
• Page End: 195
• Publication Date: 2019-04
• Subjects: HA hyaluronan -- HABP hyaluronan-binding protein -- DC dendritic cell(s) -- LPS lipopolysaccharide -- DAMP damage-associated molecular pattern; Hyaluronan -- Damage-associated molecular pattern -- TLR4 -- CD44; Dermatology -- Periodicals; Skin Diseases -- Periodicals; Dermatologie -- Périodiques; 616.5005
• DOI: 10.1016/j.jdermsci.2019.01.009
• Languages: English
• ISSNs: 0923-1811

Abstract

Abstract: Hyaluronan (HA), a linear non-sulfated glycosaminoglycan, participates in a variety of biological processes in the skin, such as cell-matrix interactions and activation of chemokines/cytokines, enzymes, and growth factors. In these activation events, HA acts as a damage-associated molecular pattern (DAMP). This review discusses the progress in functional research on HA, and its associated factors, in several aspects of cutaneous biology; e . g ., immunity and wound repair.