Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study. (8th December 2010)

• Record Type: Journal Article
• Authors: Benjamin, Ashlee M.; Suchindran, Sunil; Pearce, Kaela; Rowell, Jennifer; Lien, Lillian F.; Guyton, John R.; McCarthy, Jeanette J.
• Other Names: Chagnon Yvon Academic Editor.
• Is Part Of: Journal of obesity. Volume 2011(2011)
• Publication Date: 2010-12-08
• Subjects: Obesity -- Periodicals; Obesity; Obesity; Electronic journals; Periodicals; Periodicals; 616.398
• DOI: 10.1155/2011/329038
• Languages: English
• ISSNs: 2090-0708

Abstract

Abstract : Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P -values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits.