Efficacy and safety of endoscopic submucosal dissection for non-ampullary duodenal polyps: A systematic review and meta-analysis. Issue 6 (June 2019)

• Record Type: Journal Article
• Authors: Watanabe, Daisuke; Hayashi, Hiroki; Kataoka, Yuki; Hashimoto, Tadayuki; Ichimasa, Katsuro; Miyachi, Hideyuki; Tanaka, Shinwa; Toyonaga, Takashi
• Is Part Of: Digestive and liver disease. Volume 51:Issue 6(2019)
• Page Start: 774
• Page End: 781
• Publication Date: 2019-06
• Subjects: Duodenal polyps -- Endoscopic submucosal dissection -- Systemic review; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2019.03.021
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background and aims: Endoscopic submucosal dissection (ESD) is commonly used to treat early-stage digestive cancer because it results in a higher frequency of en-bloc resection and a lower frequency of local recurrence. However, the efficacy and safety of duodenal ESD remain unclear. Therefore, present study is aimed at evaluating clinical outcomes of duodenal ESD. Methods: To evaluate the efficacy and safety of duodenal ESD, electronic databases (MEDLINE, CENTRAL and EMBASE) were searched by two independent reviewers. The authors were contacted for additional information. A meta-analysis was performed to evaluate the efficacy and safety of duodenal ESD. Results: A total of 7 studies (203 patients) were included in the quantitative synthesis analysis. The pooled proportions of the frequencies of en-bloc resection, need for surgical intervention, bleeding, intraoperative perforation and delayed perforation were 87%, 4%, 2%, 15% and 2%, respectively. The quality of evidence regarding on surgical intervention outcomes was rated as moderate, whereas that of en-bloc resection was rated as low because of its marked inconsistency. Conclusions: Duodenal ESD produced acceptable outcomes in terms of the en-bloc R0 resection, but the incidence of procedure-related adverse events is high (PROSPERO register, CRD42017057110).