Fungus Among Us: The Frenemies Within. Issue 6 (June 2019)

• Record Type: Journal Article
• Authors: Aggor, Felix E.Y.; Way, Sing Sing; Gaffen, Sarah L.
• Is Part Of: Trends in immunology. Volume 40:Issue 6(2019)
• Page Start: 469
• Page End: 471
• Publication Date: 2019-06
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2019.04.007
• Languages: English
• ISSNs: 1471-4906

Abstract

Abstract : A recent study shows that the commensal fungus Candida albicans is an inducer of differentiation of human CD4 + Th17 cells that harbor heterologous specificity for other fungi, which may explain evolutionary benefits of C. albicans as a commensal microbe (Bacher et al. Cell 2019;176;1340–1355). However, Th17 cells that are crossreactive to Aspergillus fumigatus antigens can also drive exaggerated airway inflammation in humans.