Predicting lymph node metastasis in pancreatobiliary cancer with magnetic resonance imaging: A prospective analysis. Issue 116 (July 2019)

• Record Type: Journal Article
• Authors: Lee, Ju Hee; Han, Sung-Sik; Hong, Eun Kyung; Cho, Hwa Jin; Joo, Jungnam; Park, Eun Young; Woo, Sang Myung; Kim, Tae Hyun; Lee, Woo Jin; Park, Sang-Jae
• Is Part Of: European journal of radiology. Issue 116(2019)
• Page Start: 1
• Page End: 7
• Publication Date: 2019-07
• Subjects: Biliary tract neoplasms -- Pancreatic neoplasms -- Lymph nodes -- Diffusion magnetic resonance imaging; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.04.007
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Objectives: To prospectively investigate the diagnostic potential of lymph node (LN) magnetic resonance (MR) imaging features. Methods: A radiologist determined the maximum diameters in the short and long axes, shape, signal intensities on T1- and T2-weighted imaging, pattern of enhancement, and apparent diffusion coefficient (ADC) on diffusion-weighted MR images of LNs and annotated measurable (≥5 mm in short-axis diameter) LNs. Surgically harvested LNs were correlated with the pathologic findings. Univariable and multivariable generalized estimating equation analyses were performed to evaluate predictive power. Results: Of 80 LNs, 29 (36.3%) were positive and 51 (63.7%) negative for metastasis. The mean short-axis diameter of metastatic LNs (10.59 ± 4.30 mm) was larger than that of benign LNs (7.96 ± 2.10 mm). The ADC was significantly ( P < 0.001) lower in metastatic than non-metastatic LNs. The area under the curve (AUC) of a univariable model using only the mean ADC was 0.845 (95% confidence interval [CI], 0.743–0.927), and the mean-ADC cutoff value for predicting LN metastasis was 0.901 × 10 −3 mm 2 /s. The AUC of a multivariable model including round shape, heterogeneous enhancement, and the mean ADC was 0.917 (95% CI, 0.845–0.972), with a sensitivity, specificity, overall accuracy, and positive and negative predictive values of 89.7%, 82.4%, 85.0%, 74.3%, and 93.3%, respectively. Conclusion: The short-axis diameter and ADC were different between benign and metastatic LNs in pancreatobiliary cancer. However, round shape, heterogeneous enhancement, and a low ADC value (<0.901 × 10 −3 mm 2 /s) may be the most reliable diagnostic features of multiple metastatic LNs.