P60-T STN DBS in Parkinson's disease: EEG microstates analysis. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Lamoš, Martin; Bočková, Martina; Klimeš, Petr; Damborská, Alena; Halámek, Josef; Jurák, Pavel; Rektor, Ivan
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 7(2019:Jul.)
• Page Start: e56
• Page End: e57
• Publication Date: 2019-07
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.04.423
• Languages: English
• ISSNs: 1388-2457

Abstract

Abstract : Background: The therapy in Parkinson's disease (PD) by deep brain stimulation (DBS) is sometimes complicated because of adverse neuropsychiatric side effects. In our study with three-stimulus visual oddball paradigm (Bočková et al., in prep.) we identified three subgroups of PD patients. Same subgroups can be found in changes of microstates parameters in EEG resting-state data during DBS ON and DBS OFF state. Methods: We acquired scalp 256-channel EEG resting-state data from 18 PD patients with DBS of subthalamic nucleus (STN) and 18 age-matched HC. We analyzed resting-state data of 5 min (PD DBS ON, PD OFF, HC). The data were preprocessed in MATLAB (bandpass filtering 1–40 Hz, independent component analysis for cardiac and eye-blinking artefact suppression, interpolation of bad channels). Cartool was used for EEG microstates analysis. Differences in calculated microstate parameters between subject groups was tested by ANOVA. Results: Four template maps (A, B, C, D; Britz et al., 2010) explaining 75.21% of global variance were identified. ANOVA testing revealed statistically significant differences in parameters mean duration, time coverage and occurrences per second for C map between HC and PD. Moreover, all parameters of A and D map were significantly different in the context of PD subgroups identified in Bočková et al., in prep. Conclusions: We showed that the diversity related to motor-cognitive performance in PD patients with STN-DBS observed during performance of oddball paradigm is reflected also in significant differences in microstates parameters in the resting-state data. Significant differences in parameters can be found also between PD and HC.