Turning mesoderm into kidney. (July 2019)

• Record Type: Journal Article
• Authors: Davidson, Alan J.; Lewis, Paula; Przepiorski, Aneta; Sander, Veronika
• Is Part Of: Seminars in cell & developmental biology. Volume 91(2019)
• Page Start: 86
• Page End: 93
• Publication Date: 2019-07
• Subjects: BMP bone morphogenic protein -- CLE caudal lateral epiblast -- E embryonic day -- FGF fibroblast growth factor -- GDF growth and differentiation factor -- GDNF Glial cell-derived neurotrophic factor -- IM intermediate mesoderm -- LPMP lateral/paraxial mesoderm progenitor -- MM metanephric mesenchyme -- NMP neuromesodermal progenitor -- RA retinoic acid -- UB ureteric bud; Kidney -- Nephron progenitor -- Intermediate mesoderm -- Mesoderm -- Embryo -- Embryonic development -- Gastrulation -- Metanephros; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2018.08.016
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesoderm forms during gastrulation/axis elongation and how it progressively gives rise to distinct renal progenitors along the rostro-caudal axis. We highlight some of the potential signalling cues and core transcription factor circuits that direct these processes, up to the point of early metanephric kidney formation.