Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy. (June 2019)

• Record Type: Journal Article
• Authors: Baig, Mohammad Hassan; Adil, Mohd; Khan, Rosina; Dhadi, Surendar; Ahmad, Khurshid; Rabbani, Gulam; Bashir, Tufail; Imran, Mohammad Azhar; Husain, Fohad Mabood; Lee, Eun Ju; Kamal, Mohammad Amjad; Choi, Inho
• Is Part Of: Seminars in cancer biology. Volume 56(2019)
• Page Start: 1
• Page End: 11
• Publication Date: 2019-06
• Subjects: uPA Urokinase plasminogen activator -- CAXII Carbonic anhydrase XII -- LDHA Lactate dehydrogenase A -- SOD Superoxide dismutase -- MMPs Matrix metalloproteinases -- ALDH1 Aldehyde dehydrogenase 1 -- ALPs Alkaline phosphatases -- CAT Catalase -- HKII Hexokinase II -- PK Pyruvate kinase -- NSE Neurone-specific enolase -- G6PD Glucose-6-phosphate dehydrogenase; Enzymes -- Cancer -- Glycolysis -- Biomarkers -- Therapy; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2017.12.003
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Extensive growth of cancer in humans is a major cause of death. Numerous studies are being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent technological advancements in medical science and research indicate molecular target therapy holds much promise in cancer treatment. In the past, therapeutic and diagnostic targeting of non-glycolytic and glycolytic enzymes in cancer have been successful, and discoveries of biomarker enzymes in cancer hold promise for therapeutic treatments. In this review, we discuss the roles of several cancer-associated enzymes that could potentially act as therapeutic targets, and place special focus on non-glycolytic and glycolytic enzymes. This review indicates that the targeting of metabolic signaling offers a promising means of developing novel anti-cancer therapies.