P28-S Involvement of lower motor neurons in Parkinson's Disease reflected in MUNE method. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Mes, Martyna; Janik, Piotr; Zalewska, Elzbieta; Gawel, Malgorzata
• Is Part Of: Clinical neurophysiology. Volume 130:Issue 7(2019:Jul.)
• Page Start: e102
• Page End: e103
• Publication Date: 2019-07
• Subjects: Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2019.04.566
• Languages: English
• ISSNs: 1388-2457

Abstract

Abstract : Lower motoneuron degeneration are not among the characteristic features of Parkinson's disease(PD), although there are single studies considering the peripheral neuron involvement in PD as a continuum of degenerative process. The aim of our study was to find out if possible lower motor neuron involvement in PD is reflected with the MUNE method (motor unit number estimation). Material and methods: 41 patients with PD (mean age 62.6 yrs; 51%M) were included. The control group consisted of 45 healthy volunteers. MUNE with multipoint incremental method was calculated in the abductor pollicis brevis (APB), the abductor digiti minimi (ADM) and the extensor digitorum brevis (EDB). Results: Significant difference in the number of motor units estimating by MUNE was found between groups aged 60 years or older in ADM comparing with control group ( p < 0.05). Single motor unit action potential (SMUP), reflecting the size of motor unit, was lower in PD group aged 31–45 and with the aged over 60 years only in APB comparing with control group. MUNE correlated negatively with the age of subjects for APB and EDB, and correlated negatively with the duration of the disease for EDB. MUNE correlated negatively with advancement of PD assessed using Unified Parkinson's Disease Rating Scale, Hoehn and Yahr Scale and Schwab and England Activites of Daily Living Scale for EDB. Conclusions: The loss of motor units in sporadic Parkinson's disease revealed by the multipoint incremental MUNE method may be considered as a sign of lower motor neuron involvement and a feature of generalized neurodegeneration.