Drosophila strain specific response to cisplatin neurotoxicity. Issue 3 (2nd October 2018)

• Record Type: Journal Article
• Authors: Groen, Christopher M.; Podratz, Jewel L.; Treb, Kevin; Windebank, Anthony J.
• Is Part Of: Fly. Volume 12:Issue 3/4(2018)
• Page Start: 174
• Page End: 182
• Publication Date: 2018-10-02
• Subjects: Drosophila -- chemotherapy-induced peripheral neuropathy -- cisplatin -- neurodegeneration -- ABC transporter -- glutathione; Drosophila -- Periodicals; 595.77
• DOI: 10.1080/19336934.2019.1565257
• Languages: English
• ISSNs: 1933-6934

Abstract

ABSTRACT: Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN.