Theoretical Investigation of the D83V Mutation within the Myocyte-Specific Enhancer Factor-2 Beta and Its Role in Cancer. (24th December 2013)

• Record Type: Journal Article
• Authors: Yakovenko, Oleksandr; Morin, Ryan; Vashchenko, Ganna; Jones, Steven J. M.
• Other Names: Rick S. W. Academic Editor.; Verli H. Academic Editor.
• Is Part Of: Journal of theoretical chemistry. Volume 2013(2013)
• Publication Date: 2013-12-24
• Subjects: Chemistry, Physical and theoretical -- Periodicals; Chemistry, Physical and theoretical; Periodicals; Electronic journals; 541.2
• DOI: 10.1155/2013/313419
• Languages: English
• ISSNs: 2356-7686

Abstract

Abstract : The D83V mutation in the myocyte-specific enhancer factor-2 beta ( MEF2B ) gene is frequently observed in lymphomas. Surprisingly, this apparent gain-of-function mutation is within a protein that is involved in the promotion of apoptosis in B cells. To investigate the oncogenic effects of this alteration and explain its predominance over other known loss-of-function mutations of MEF2B, we propose a hypothesis that this mutation influences the dynamic folding of the C-terminal loop of the N-terminal domain of MEF2B. According to our hypothesis, the mutation allows MEF2B to bind promiscuously to a wider variety of gene promoters. A large set of molecular dynamic simulations (MD) was conducted to investigate the effects of D83V mutation in silico and support the hypothesis.