Antimutagenic activity of flavonoids from Sozuku. Issue 6 (19th March 2019)

• Record Type: Journal Article
• Authors: Okuno, Yoshiharu; Marumoto, Shinsuke; Miyazawa, Mitsuo
• Is Part Of: Natural product research. Volume 33:Issue 6(2019)
• Page Start: 862
• Page End: 865
• Publication Date: 2019-03-19
• Subjects: Sozuku -- Alpinia katsumadae Hayata -- pinocembrin -- cardamonin -- antimutagenic activity -- umu test -- Ames test; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1408104
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Pinocembrin (1 ) and cardamonin (2 ) from Sozuku showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen furylfuramide. Compounds1 and2 suppressed 52% and 36% of SOS-inducing activity at a concentration of 0.20 μmol/mL. The ID50 value of1 was 0.18 μmol/mL. These compounds showed the suppression of 2-amino-3, 4-dimethylimidazo-[4, 5-f]quinolone (MeIQ) and UV irradiation-induced SOS response. Pinostrobin (3 ) and 5, 7-dimethoxyflavanone (4 ), methyl ethers of1, showed similar activity to1 against MeIQ-induced SOS response, but that of furylfuramide and UV irradiation were decreased. On the other hand, compounds1 –4 did not show the suppression of activated MeIQ-induced SOS response. Furthermore, compounds1 –4 showed potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains. Abstract :