Chemical and pharmacological comparison of modern and traditional dosage forms of Joshanda. Issue 6 (19th March 2019)

• Record Type: Journal Article
• Authors: Parveen, Sajida; Irfan Bukhari, Nadeem; Shehzadi, Naureen; Qamar, Shaista; Ali, Ejaz; Naheed, Surriya; Latif, Abida; Yuchi, Alamgeer; Hussain, Khalid
• Is Part Of: Natural product research. Volume 33:Issue 6(2019)
• Page Start: 858
• Page End: 861
• Publication Date: 2019-03-19
• Subjects: Joshanda -- standardisation -- physicochemical studies -- pharmacological variations; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1408103
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Recently, a traditional remedy ( Joshanda) has been replaced largely by modern ready-to-use dosage forms, which have not been compared to the original remedy. Therefore, the present study aimed to compare a number of modern dosage forms with traditional remedy. Seven brands, 3 batches each, were compared with a Lab-made formulation with reference to analytical (proximate analyses, spectroscopic and chromatographic metabolomes) and pharmacological profiles (anti-inflammatory and antibacterial activities). Chemical and pharmacological differences were found between Lab-made Joshanda and modern dosage forms. Such variations were also found within the brands and batches of modern formulations ( p < 0.05). The Lab-made Joshanda showed significantly higher pharmacological activities as compared to modern brands ( p ). The results of the present study indicate that modern dosage forms are unstandardised and less effective than the traditional remedy. Characteristic profiles obtained from Lab-made Joshanda may be used as reference to produce comparable dosage forms. Abstract :