Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt–Koyanagi–Harada Disease Using Swept-Source Optical Coherence Tomography. (17th February 2019)

• Record Type: Journal Article
• Authors: Jaisankar, Durgasri; Raman, Rajiv; Sharma, Hitesh R.; Khandelwal, Neha; Bhende, Muna; Agrawal, Rupesh; Sridharan, Sudharshan; Biswas, Jyotirmay
• Is Part Of: Ocular immunology and inflammation. Volume 27:Number 2(2019)
• Page Start: 235
• Page End: 243
• Publication Date: 2019-02-17
• Subjects: Choroidal and retinal thicknesses -- choroidal vascularity index -- swept- source optical coherence tomography -- systemic steroid response -- Vogt–Koyanagi–Harada disease; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2017.1332231
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To assess structural changes in retina and choroid after systemic corticosteroid therapy in Vogt–Koyanagi–Harada (VKH) disease using swept-source optical coherence tomography (SS-OCT). Methods : SS-OCT was conducted before treatment and during first-month follow-up in 16 eyes treated with systemic corticosteroids for active VKH. Retina was divided into five zones depending on pretreatment choroidal thickness (CT) of <100, >100 to <200, >200 to <300, >300 to <400 and >400μm, and changes in retinal thickness and CT after treatment in these zones were compared with baseline. Results : Mean CT significantly improved from 83.1±8.75 to 156.4±62.73μm( p = 0.008) in the zone with pre-CT <100μm and significantly decreased from 336.1 ± 17.28 to 266.28 ± 81.39μm( p = 0.008) in the zone with pre-CT > 300μm. Conclusions : We have shown choroidal remodeling in VKH. SS-OCT can serve as an important noninvasive tool in assessment of treatment response in patients with VKH disease.