IκB, NF-κB Regulation Model: Simulation Analysis of Small Number of Molecules. (24th January 2008)

• Record Type: Journal Article
• Authors: Sarkar, Anamika; Meila, Marina; Franza, Robert B.
• Other Names: Wang Yue Academic Editor.
• Is Part Of: EURASIP journal on bioinformatics and systems biology. Volume 2007(2007)
• Publication Date: 2008-01-24
• Subjects: Bioinformatics -- Periodicals; Systems biology -- Periodicals; Systems Biology; Signal Processing, Computer-Assisted; Bio-informatique; Biologie systémique; Bioinformatics; Systems biology; Systems Biology; Bioinformatics; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 570.285
• DOI: 10.1155/2007/25250
• Languages: English
• ISSNs: 1687-4145

Abstract

Abstract : The regulation of Iκ B, NF-κ B is of foremost interest in biology as the transcription factor NF-κ B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of Iκ B, NF-κ B mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF-κ B oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.