Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites. Issue 2 (29th November 2018)

• Record Type: Journal Article
• Authors: Aguiar, Luísa; Machado, Marta; Sanches-Vaz, Margarida; Prudêncio, Miguel; Vale, Nuno; Gomes, Paula
• Is Part Of: MedChemComm. Volume 10:Issue 2(2019)
• Page Start: 221
• Page End: 226
• Publication Date: 2018-11-29
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c8md00447a
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : Novel primaquine–cell penetrating peptide conjugates were synthesised and tested in vitro against liver stage Plasmodium berghei parasites, showing that generally the conjugates were more active than the parent peptides and, in some cases, than the parent drug. Abstract : Novel primaquine–cell penetrating peptide conjugates were synthesised and tested in vitro against liver stage Plasmodium berghei parasites. Generally, the conjugates were more active than the parent peptides and, in some cases, than the parent drug. These are unprecedented findings that may open a new route towards antimalarial drug rescuing.