Monitoring transient cell-to-cell interactions in a multi-layered and multi-functional allergy-on-a-chip system. Issue 11 (9th May 2019)

• Record Type: Journal Article
• Authors: Rothbauer, Mario; Charwat, Verena; Bachmann, Barbara; Sticker, Drago; Novak, Richard; Wanzenböck, Heinz; Mathies, Richard A.; Ertl, Peter
• Is Part Of: Lab on a chip. Volume 19:Issue 11(2019)
• Page Start: 1916
• Page End: 1921
• Publication Date: 2019-05-09
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c9lc00108e
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : Multi-functional LOC for transient allergy monitoring. Abstract : We have developed a highly integrated lab-on-a-chip containing embedded electrical microsensors, μdegassers and pneumatically-actuated micropumps to monitor allergic hypersensitivity. Rapid antigen-mediated histamine release ( e.g. s to min) and resulting muscle contraction (<30 min) is detected by connecting an immune compartment containing sensitized basophile cells to a vascular co-culture model.