Higher intake of coagulase-negative staphylococci from maternal milk promotes gut colonization with mecA-negative Staphylococcus epidermidis in preterm neonates. (October 2018)

• Record Type: Journal Article
• Authors: Soeorg, Hiie; Treumuth, Sirli; Metsvaht, Hanna; Eelmäe, Imbi; Merila, Mirjam; Ilmoja, Mari-Liis; Lutsar, Irja; Metsvaht, Tuuli
• Is Part Of: Journal of perinatology. Volume 38:Number 10(2018)
• Page Start: 1344
• Page End: 1352
• Publication Date: 2018-10
• Subjects: Perinatology -- Periodicals; 618.32005
• DOI: 10.1038/s41372-018-0183-y
• Languages: English
• ISSNs: 0743-8346

Abstract

Abstract Objective We aimed to determine factors associated with gut colonization of preterm neonates with coagulase-negative staphylococci (CoNS) from maternal milk (MM). Study Design CoNS isolated from weekly collected stool and MM of hospitalized preterm (n = 49) and healthy term neonates (n = 20) were genotyped. Colonization-related factors were determined by Cox proportional hazards regression. Result Gut colonization withmecA -negativeSta p hylococcus e p idermidis from MM was less prevalent (40.8% vs. 95%) and delayed (median age 15.5 vs. 2 days) in preterm compared with term neonates. Enhanced colonization was associated with higher intake of CoNS from MM (hazard ratio (95% confidence interval) 1.006 (1.00–1.01) for 106 colony-forming units), lower proportion ofmecA -positive predominant NICU strains in gut (0.09 (0.01–0.49) for 1%) and lower incidence of late-onset CoNS sepsis (5% vs. 34% in those without colonization). Conclusion Enteral feeding with larger proportion of unpasteurized MM and limiting spread of predominant strains may promote colonization with CoNS from MM.