Digital Ischemia in Scleroderma Spectrum of Diseases. (26th July 2010)

• Record Type: Journal Article
• Authors: Schiopu, Elena; Impens, Ann J.; Phillips, Kristine
• Other Names: Chung Lorinda Academic Editor.
• Is Part Of: International journal of rheumatology. Volume 2010(2010)
• Publication Date: 2010-07-26
• Subjects: Rheumatology -- Periodicals; Rheumatology; Rheumatology; Electronic journals; Periodicals; Periodicals; 616.723
• DOI: 10.1155/2010/923743
• Languages: English
• ISSNs: 1687-9260

Abstract

Abstract : Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the hallmark of SSc-related vasculopathy and is characterized by endothelial dysfunction leading to intimal proliferation and thrombosis. It happens frequently (30% of the patients each year) and it is associated with significant morbidity. This paper summarizes the current information regarding pathogenesis, definitions, management, and exploratory therapies in DUs associated with SSc.