Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma. (11th March 2013)

• Record Type: Journal Article
• Authors: Schoenberger, Scott D.; Kim, Stephen J.
• Other Names: Hayashi T. Academic Editor.; Johnson S. M. Academic Editor.; Machida S. Academic Editor.; Rosner M. Academic Editor.; Schwartz S. Academic Editor.
• Is Part Of: Case reports in ophthalmological medicine. Volume 2013(2013)
• Publication Date: 2013-03-11
• Subjects: Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Ophthalmology; Eye Diseases; Eye -- Diseases; Ophthalmology; Electronic journals; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617.7
• DOI: 10.1155/2013/673796
• Languages: English
• ISSNs: 2090-6722

Abstract

Abstract : Newer chemotherapeutic agents target extracellular signaling, including the mitogen-activated protein kinase kinase (MEK) pathway. We present a case of a 54-year-old female who developed bilateral multifocal central serous-like chorioretinopathy shortly after starting MEK inhibition for metastatic cutaneous melanoma. There was a complete resolution of findings after drug stoppage. After resuming a lower dose of the MEK inhibitor, the findings recurred again but resolved after drug stoppage. Other etiologies were unlikely given the clinical course. The presumed mechanism involves toxicity to the retinal pigment epithelium, with breakdown of the blood-retinal barrier. Recognition of this side effect is important with this new class of chemotherapy.