Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds. Issue 11 (9th April 2019)

• Record Type: Journal Article
• Authors: Peng, Xiaofeng; Zhang, Xiaofei; Li, Shunyao; Lu, Yunfu; Lan, Lefu; Yang, Chunhao
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 11(2019)
• Page Start: 1775
• Page End: 1779
• Publication Date: 2019-04-09
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00324j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Herein, a simple and regioselective synthesis of (2-hydroxyphenyl)(3-(trifluoromethyl/cyano/phosphonate)-1 H -pyrazol-5-yl)methanones as pyrrolomycin analogues was reported. Abstract : Herein, a simple and regioselective synthesis of (2-hydroxyphenyl)(3-(trifluoromethyl/cyano/phosphonate)-1 H -pyrazol-5-yl)methanones as pyrrolomycin analogues was reported. This reaction could proceed from 3-formylchromones and the corresponding diazo compounds by a silver-mediated one-pot cascade reaction under mild conditions with a broad substrate scope. Most of all, some products displayed potent antibacterial activities.