Cover Feature: A Ring‐Distortion Strategy from Marine Natural Product Ilimaquinone Leads to Quorum Sensing Modulators (Eur. J. Org. Chem. 20‐21/2018). Issue 20 (25th May 2018)

• Record Type: Journal Article
• Authors: Evanno, Laurent; Lachkar, David; Lamali, Assia; Boufridi, Asmaa; Séon‐Méniel, Blandine; Tintillier, Florent; Saulnier, Denis; Denis, Stéphanie; Genta‐Jouve, Grégory; Jullian, Jean‐Christophe; Leblanc, Karine; Beniddir, Mehdi A.; Petek, Sylvain; Debitus, Cécile; Poupon, Erwan
• Is Part Of: European journal of organic chemistry. Issue 20/21(2018)
• Page Start: 2295
• Page End: 2295
• Publication Date: 2018-05-25
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201800740
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Cover Feature shows a ring‐distortion strategy applied to the marine natural product ilimaquinone. A chemically diverse library of molecules was synthesised that included rearrangements of the sesquiterpene moiety and original reorganisations of the quinone ring. Compounds were evaluated as quorum sensing inhibitors of Vibrio Harveyi, an economically important pathogen in French Polynesia. This work is depicted in a festive theme for the special issue celebrating the 20th anniversary of the journal. More information can be found in theFull Paper by L. Evanno, E. Poupon et al.