Protein Biomarkers for the Early Detection of Breast Cancer. (11th August 2011)

• Record Type: Journal Article
• Authors: Misek, David E.; Kim, Evelyn H.
• Other Names: Kondo Tadashi Academic Editor.
• Is Part Of: International journal of proteomics. Volume 2011(2011)
• Publication Date: 2011-08-11
• Subjects: Proteomics -- Periodicals; Proteomics; Proteomics; Electronic journals; Periodical; Fulltext; Internet Resources; Periodicals; Periodicals; 572.6
• DOI: 10.1155/2011/343582
• Languages: English
• ISSNs: 2090-2166

Abstract

Abstract : Advances in breast cancer control will be greatly aided by early detection so as to diagnose and treat breast cancer in its preinvasive state prior to metastasis. For breast cancer, the second leading cause of cancer-related death among women in the United States, early detection does allow for increased treatment options, including surgical resection, with a corresponding better patient response. Unfortunately, however, many patients' tumors are diagnosed following metastasis, thus making it more difficult to successfully treat the malignancy. There are, at present, no existing validated plasma/serum biomarkers for breast cancer. Only a few biomarkers (such as HER-2/neu, estrogen receptor, and progesterone receptor) have utility for diagnosis and prognosis. Thus, there is a great need for new biomarkers for breast cancer. This paper will focus on the identification of new serum protein biomarkers with utility for the early detection of breast cancer.