Malignant Peripheral Nerve Sheath Tumor of Prostate: A Rare Case Report and Literature Review. (30th October 2016)

• Record Type: Journal Article
• Authors: Hsieh, Kun-Lin; Lu, Chih-Cheng; Li, Chien-Feng; Feng, Yin-Hsun; Liao, Alex C.
• Other Names: Carmignani Giorgio Academic Editor.
• Is Part Of: Case reports in urology. Volume 2016(2016)
• Publication Date: 2016-10-30
• Subjects: Urology -- Periodicals; Urology -- Case studies -- Periodicals; Genitourinary organs -- Diseases -- Periodicals; Urologic Diseases; Genitourinary organs -- Diseases; Urology; Periodicals; Case studies; Periodicals; 616.6005
• DOI: 10.1155/2016/9317567
• Languages: English
• ISSNs: 2090-696X

Abstract

Abstract : A mid-aged male presented with progressive lower urinary tract symptoms (LUTS) for years. Huge prostate with low serum prostate-specific antigen (PSA) level was detected. The specimen from transurethral resection revealed surprising pathology finding as malignant peripheral nerve sheath tumor (MPNST). Considering its huge size (more than 300 gm) and location, we prescribed neoadjuvant chemotherapy firstly. The tumor became regressive and then radical surgical resection was achieved. Adjuvant multimodality treatment including concurrent chemoradiotherapy (CCRT) and target therapy was given. However, he expired about one year later. MPNST originating from prostate is very rare and seldom reported before. We here present this extremely rare disease and share our treatment experience.